èšåºæ®µéã®ãã€ãªå»è¬åäŒç€Ÿã§ãã Calithera Biosciences, Inc. ã¯ãç±³åœã§ã®çæ²»çãç®çãšãããè
«ç代è¬ããã³è
«çå
ç«åŠçæšçã«å¯Ÿããäœååå»è¬åã®çºèŠãšéçºã«æ³šåããŠããŸããäž»å補ååè£ã¯ã°ã«ã¿ãããŒãŒé»å®³å€ CB-839 ã§ãåºåœ¢è
«çã®æ²»çãç®çãšãã第 II çžèšåºè©Šéšäžã§ããå瀟ã¯ãŸããè¡æ¶²åŠããã³è
«çåŠã®æ²»çãç®çãšãã第 I/II çžèšåºè©Šéšäžã®çµå£ã¢ã«ã®ããŒãŒé»å®³å€ INCB001158 ãæäŸããŠããŸããå瀟ã¯ãŸããå¢èæ§ç·ç¶çããã³æ
¢æ§æ°éææçã®æ²»çãç®çãšãã第 Ib çžèšåºè©Šéšäžã®çµå£ã¢ã«ã®ããŒãŒé»å®³å€ CB-280ãçµå£æäžã®äœåå CD73 é»å®³å€ CB-708ãããã³é
µçŽ IL4I1 é»å®³å€ CB-668 ãéçºäžã§ããå瀟ã¯ãããŒã¹ç€Ÿãšã©ã€ã»ã³ã¹å¥çŽãçµã³ãSymbioscience 瀟ã®ã¢ã«ã®ããŒãŒé»å®³å€ããŒããã©ãªãªã人éã®å»çã«äœ¿çšããããã«éçºããã³åååããŠããŸãããŸããå瀟ã¯ãã¡ã€ã¶ãŒç€Ÿãšèšåºè©Šéšã®ååé¢ä¿ã«ããããã¡ã€ã¶ãŒç€Ÿã® PARP é»å®³å€ã¿ã©ãŸããªãããã³ CDK4/6 é»å®³å€ãã«ãã·ã¯ãªãããããããã©ã°ã¬ãã¹ã¿ãšçµã¿åãããŠè©äŸ¡ããŠããŸããããã«ãå瀟ã¯ãè¡æ¶²åŠããã³è
«çåŠã®æ²»çã®ããã®å°ååã¢ã«ã®ããŒãŒé»å®³å€ INCB001158 ã®ç ç©¶ãéçºãããã³åååã«é¢ããŠã€ã³ãµã€ã瀟ãšååããã³ã©ã€ã»ã³ã¹å¥çŽãçµãã§ããŸãããŸããCB-708 ã®éçºããã³åååã«é¢ããŠã¢ã³ãã³ãžãŒã³ç€Ÿãšã©ã€ã»ã³ã¹å¥çŽãçµãã§ããŸããã«ãªã»ã© ãã€ãªãµã€ãšã³ã¹ç€Ÿã¯ 2010 幎ã«èšç«ãããã«ãªãã©ã«ãã¢å·ãµãŠã¹ãµã³ãã©ã³ã·ã¹ã³ã«æ¬ç€Ÿã眮ããŠããŸãã